Decellularized extracellular matrix from senescent cells

1. Decellularized extracellular matrix from senescent cells increase senescence markers in mice.

   “when discs coated with S-ECM were implanted in young mice, an increase in senescence markers was observed compared to mice implanted with discs coated with P-ECM.”

   Animalsdiscs coated with S-ECM implanted

   Extracellular matrix-associated molecules of senescent cells induce a senescence phenotype in proliferative cells via TGF-β signaling pathway

   Biomaterials·8 Apr 2026

More on Senescence markers

1. Decellularized extracellular matrix from senescent cells induce cellular senescence in human cells.

   “decellularized ECM from senescent vascular smooth muscle cells (S-ECM) or fibroblasts, but not from proliferating cells (P-ECM), robustly induces a senescence phenotype in human proliferative endothelial cells”

   Cellstwo-week culture periodendothelial cellstwo weeks

   Extracellular matrix-associated molecules of senescent cells induce a senescence phenotype in proliferative cells via TGF-β signaling pathway

   Biomaterials·8 Apr 2026

More on Cellular senescence