Daumone

1. Daumone decreases hepatic fibrosis in mice.

   “The increased hepatic hypertrophy, senescence-associated β-galactosidase activity, insulin resistance, lipid accumulation, inflammation, oxidative stress, and fibrosis in old mice were significantly attenuated by daumone.”

   Animalsoralliver2 mg kg(-1) day(-1)5 monthsmales

   Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

   Aging cell·6 May 2014

1. Daumone decreases inflammation in mice.

   “The increased hepatic hypertrophy, senescence-associated β-galactosidase activity, insulin resistance, lipid accumulation, inflammation, oxidative stress, and fibrosis in old mice were significantly attenuated by daumone.”

   Animalsoralliver2 mg kg(-1) day(-1)5 monthsmales

   Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

   Aging cell·6 May 2014

More on Inflammation

1. Daumone decreases insulin in mice.

   “the increased plasma insulin normally presented in old mice was significantly reduced by daumone.”

   Animalsoralplasma2 mg kg(-1) day(-1)5 monthsmales

   Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

   Aging cell·6 May 2014

More on Insulin

1. Daumone extends lifespan in mice (-48% risk of death).

   “Daumone was found to reduce the risk of death by 48% compared with age-matched control mice”

   Animalsoralwhole body2 mg kg(-1) day(-1)5 monthsmales

   Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

   Aging cell·6 May 2014