Dactolisib
- 1 lab in 1 country
- Funders: Fonds De La Recherche Scientifique - FNRS and 1 more
- Animals1
Outcomes
3Primordial follicles
upin mice1
1 study
Primordial follicles
upin mice1
Dactolisib increases primordial follicles in mice.
“In vivo, ovaries slow-frozen with BEZ235 retained a higher percentage of primordial follicles”
Animalsthree weeks after autotransplantation under kidney capsulethree weeks
BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model
Reproductive biology and endocrinology : RB&E19 Jun 2025
PI3K–AKT signalling
downin mouse cells1
1 study
PI3K–AKT signalling
downin mouse cells1
Dactolisib inhibits PI3K–AKT signalling in mouse cells.
“In vitro, BEZ235 significantly counteracted chemotherapy-induced activation of both Akt and mTOR pathways”
Cellsin organotypic ovarian culture treated with 4-HC1 μM
BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model
Reproductive biology and endocrinology : RB&E19 Jun 2025
mTOR signalling
downin mouse cells1
1 study
mTOR signalling
downin mouse cells1
Dactolisib inhibits mTOR signalling in mouse cells.
“In vitro, BEZ235 significantly counteracted chemotherapy-induced activation of both Akt and mTOR pathways”
Cellsin organotypic ovarian culture treated with 4-HC1 μM
BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model
Reproductive biology and endocrinology : RB&E19 Jun 2025