D-mc-αa

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Model organisms1

Outcomes

Amyloid-β-induced mortality

downin worms1

1 study

D-mc-αa decreases amyloid-β-induced mortality in worms.
“D-MC-αA provided greater protection than MC-αA against amyloid-β-induced paralysis and mortality.”
Model organismsCompared with MC-αA
A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity
Free radical biology & medicine13 Oct 2026

Amyloid-beta-induced paralysis

downin worms1

1 study

D-mc-αa protects against amyloid-beta-induced paralysis in worms.
“D-MC-αA provided greater protection than MC-αA against amyloid-β-induced paralysis and mortality.”
Model organismsCompared with MC-αA
A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity
Free radical biology & medicine13 Oct 2026

Lifespan

upin worms1

1 study

D-mc-αa extends lifespan in worms.
“both peptides significantly extended lifespan”
Model organisms
A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity
Free radical biology & medicine13 Oct 2026

Chaperone activity

upin cells1

1 study

D-mc-αa increases chaperone activity in cells (Approximately threefold greater than MC-αA).
“D-MC-αA exhibited approximately threefold greater chaperone activity than MC-αA”
CellsBiochemical assay; compared with MC-αAall-D-amino acid analog
A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity
Free radical biology & medicine13 Oct 2026

Latest

1 in 12 months

Free Radical Biology & Medicine1 h

A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity

Experiments in wormsInterventions

Paper

D-mc-αa

Outcomes

Latest

A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity

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