D-mannose

Intervention1 paper4 findingsPubChem 18950ChEBI 4208

Animals1

Outcomes

4

Autophagy

upin mouse cells1Very low certainty

1 study

D-mannose activates autophagy in mouse cells.
Cellsduring senescenceskin fibroblast
Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation · Materials today. Bio · 21 Aug 2026

SIRT1

downin mouse cells1Very low certainty

1 study

D-mannose protects against SIRT1 in mouse cells.
Cellsduring senescenceskin fibroblast
Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation · Materials today. Bio · 21 Aug 2026

Extracellular matrix disposition

upin mice1Very low certainty

1 study

D-mannose improves extracellular matrix disposition in mice.
Animalsskin
Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation · Materials today. Bio · 21 Aug 2026

Senescent phenotype

downin mice1Very low certainty

1 study

D-mannose decreases senescent phenotype in mice.
AnimalsMSN-B-Manskin
Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation · Materials today. Bio · 21 Aug 2026

Latest

1

Materials Today BioAnimals13 Sep

Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation