Cytotoxic chemotherapy
1 paper2 findings
- 1 lab in 1 country
- Funders: Breast Cancer Research Foundation and 7 more
- Humans1
Outcomes
2DNAm-Horvath, PhenoAge, GrimAge and mPoA
no changein humans1
1 study
DNAm-Horvath, PhenoAge, GrimAge and mPoA
no changein humans1
Cytotoxic chemotherapy has no effect on DNAm-Horvath, PhenoAge, GrimAge and mPoA in humans.
“increased expression of p16 but not levels of the most common epigenetic clocks (DNAm-Horvath, PhenoAge, GrimAge, mPoA), with the exception of DNAm-Hannum.”
Humanspatients undergoing cytotoxic chemotherapy treatmentn = 48
medRxiv14 May 2023Preprint
P16 expression
upin humans1
1 study
P16 expression
upin humans1
Cytotoxic chemotherapy increases P16 expression in humans.
“Chemotherapy, a known clinically-relevant inducer of aging, increased expression of p16”
Humanspatients undergoing cytotoxic chemotherapy treatmentn = 48
medRxiv14 May 2023Preprint
Latest
medRxiv
Performance of cellular senescence measure, p16, and DNA methylation clocks in a clinically relevant model of age acceleration
Preprint: cohort study of 251 peopleInterventions