Cystamine dihydrochloride

1. Cystamine dihydrochloride decreases SASP in mice.

   “attenuates senescence-associated secretory phenotype (SASP) and reactive oxygen species (ROS) levels”

   Animalspharmacological inhibition with cystamine dihydrochloride

   TGM2 drives microglial senescence by inhibiting autophagy via the PI3K/AKT/mTORC1 pathway

   Free radical biology & medicine·28 May 2026

More on SASP

1. Cystamine dihydrochloride increases autophagy in mice.

   “Pharmacological inhibition of TGM2 with cystamine dihydrochloride (CD) reduces this complex, restores autophagy”

   Animalspharmacological inhibition with cystamine dihydrochloride

   TGM2 drives microglial senescence by inhibiting autophagy via the PI3K/AKT/mTORC1 pathway

   Free radical biology & medicine·28 May 2026

More on Autophagy

1. Cystamine dihydrochloride improves motor deficit in mice.

   “significantly reverses cognitive and motor deficits in aged mice”

   Animalsin aged mice

   TGM2 drives microglial senescence by inhibiting autophagy via the PI3K/AKT/mTORC1 pathway

   Free radical biology & medicine·28 May 2026

1. Cystamine dihydrochloride improves cognitive deficit in mice.

   “significantly reverses cognitive and motor deficits in aged mice”

   Animalsin aged mice

   TGM2 drives microglial senescence by inhibiting autophagy via the PI3K/AKT/mTORC1 pathway

   Free radical biology & medicine·28 May 2026

1. Cystamine dihydrochloride extends lifespan in mice.

   “administration of cystamine in drinking water delayed the age of onset for motor dysfunction and extended lifespan”

   Animalsin R6/2 micein drinking water

   The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase

   Neurobiology of aging·1 Jun 2006

1. Cystamine dihydrochloride prevents motor dysfunction in mice.

   “administration of cystamine in drinking water delayed the age of onset for motor dysfunction and extended lifespan”

   Animalsin R6/2 micein drinking water

   The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase

   Neurobiology of aging·1 Jun 2006