CX-5461

CX-5461 has been studied in 2 papers since 2022: none in people yet, 2 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 26, 2026: “Blocking ribosome production caused kidney scarring in mice”.

Intervention

2 papers study it1 more mentions it4 findingsUpdated Oct 16, 2026

PubChem ChEBI

1 new paper in 30 daysSee all 3

None of its findings points the other way.

3 independent labs in 2 countries

Funders: Deutsche Forschungsgemeinschaft and 7 more

Animals2

What did studies of CX-5461 find?

Studies of CX-5461 measured 3 outcomes; the most studied are cellular senescence (2 studies), renal interstitial fibrosis (1) and stem cell differentiation (1).

Cellular senescence

upin cells1upin human cells1

2 studies

CX-5461 induces cellular senescence in cells.
“Exposure to nucleolar stress inducers CX-5461 and actinomycin D (ActD) resulted in senescence-associated β-gal staining (SA-β-gal) activity in cultured β cells.”
Cellsin cultured beta cells
Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways
iScienceSep 4, 2025
CX-5461 induces cellular senescence in human cells.
“CX5461-induced growth arrest is irreversible and exhibits features of senescence and terminal differentiation.”
Cellsin colorectal cancer cells
RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells
Molecular oncologyJun 9, 2022

Latest

1 paper in 12 months

CellsOct 26

Blocking ribosome production caused kidney scarring in mice

In mouse experiments, a drug that blocked production of cells’ protein-making machinery caused kidney scarring before kidney function declined.In mouse experiments, a drug that blocked production of cells’ protein-making machinery caused kidney scarring before kidney function declined.

Mouse studyKidney