AgingResearch.NewsJoin free

CTBP2

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 6 more
  • Animals1

Outcomes

3

CYB5R3

upin mice1

1 study

  1. CTBP2 activates CYB5R3 in mice.

    “Mechanistically, we identify activation of CYB5R3 and AMPK downstream of exosomal CtBP2.”

    Animals

    The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan

    Nature aging8 Oct 2025

More on CYB5R3

Frailty

downin mice1

1 study

  1. CTBP2 decreases frailty in mice.

    “improves healthspan in particular by reducing frailty”

    Animals

    The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan

    Nature aging8 Oct 2025

Lifespan

upin mice1

1 study

  1. CTBP2 extends lifespan in mice.

    “Exosomal CtBP2 administration extends lifespan in aged mice”

    Animals

    The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan

    Nature aging8 Oct 2025

Latest

Related