Cross-linked hyaluronate + dexamethasone

1. Cross-linked hyaluronate + dexamethasone decreases cellular senescence in rats.

   “while suppressing senescence and inflammation marker expressions.”

   Animalsin a rat OA modelknee joint

   Suppression of experimental knee osteoarthritis by combination therapy of cross-linked hyaluronate and corticosteroids via anti-senescent effects

   International journal of biological macromolecules·24 Mar 2025

2. Cross-linked hyaluronate + dexamethasone decreases cellular senescence in human cells.

   “Formulations of cHA(50:50) + DEX and cHA(20:80) + DEX effectively shielded chondrocytes from DEX-induced cytotoxicity and senescence”

   Cellsin cultured human OA chondrocytes

   Suppression of experimental knee osteoarthritis by combination therapy of cross-linked hyaluronate and corticosteroids via anti-senescent effects

   International journal of biological macromolecules·24 Mar 2025

More on Cellular senescence

1. Cross-linked hyaluronate + dexamethasone improves dynamic weight bearing ratio in rats (p < 0.05).

   “In the rat OA model, cHA(50:50) + DEX significantly ameliorated OA features, including histological scores and dynamic weight bearing ratio (p < 0.05, both)”

   Animalsin a rat OA modelknee joint

   Suppression of experimental knee osteoarthritis by combination therapy of cross-linked hyaluronate and corticosteroids via anti-senescent effects

   International journal of biological macromolecules·24 Mar 2025

1. Cross-linked hyaluronate + dexamethasone decreases osteoarthritis in rats (p < 0.05).

   “In the rat OA model, cHA(50:50) + DEX significantly ameliorated OA features, including histological scores and dynamic weight bearing ratio (p < 0.05, both)”

   Animalsin a rat OA modelknee joint

   Suppression of experimental knee osteoarthritis by combination therapy of cross-linked hyaluronate and corticosteroids via anti-senescent effects

   International journal of biological macromolecules·24 Mar 2025

More on Osteoarthritis