Crocin i

1 paper5 findings

In human WI-38 cells, crocin I decreases lactate and reactive oxygen species and increases SIRT1; it also reduces senescence-associated beta-galactosidase in replicative and premature senescence and increases proliferation at 10–40 μM. The work comes from one lab, without independent replication or studies in humans.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Cells1

Outcomes

Lactate

downin human cells1

1 study

Crocin i decreases lactate in human cells.
CellsWI-38 cells
Crocin I delays cellular senescence potentially via modulating SIRT1/PKM2 expression to improve lactate homeostasis in vitro
Experimental and therapeutic medicine29 Jul 2026

Latest

2 in 12 months

Experimental and Therapeutic Medicine11 Aug

Crocin I delays cellular senescence potentially via modulating SIRT1/PKM2 expression to improve lactate homeostasis in vitro

Experiments in human cellsInterventions

Paper

Frontiers in Molecular Neuroscience6 Aug

Crocus sativus improves cognitive functions and reduces anxiety-like behavior in aged rats exposed to chronic cold temperature-induced stress

Experiments in ratsInterventions