Concave niche topography
1 paper2 findings
- 1 lab in 1 country
- Funder: National Institute on Aging
- Humans1
Outcomes
2Cell cycle–associated gene expression
downin human cells1
1 study
Cell cycle–associated gene expression
downin human cells1
Concave niche topography decreases cell cycle–associated gene expression in human cells.
“Transcriptomic analysis revealed that concave niches promoted keratinocyte differentiation, marked by increased type I and II keratin gene expression and downregulation of cell cycle–associated genes.”
Cellsconcave topography compared with a flat matrix3D-bioprinted collagen matricesepidermal stem cell
Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging
bioRxiv (Cold Spring Harbor Laboratory)10 Apr 2026Preprint
keratinocyte differentiation
upin human cells1
1 study
keratinocyte differentiation
upin human cells1
Concave niche topography increases keratinocyte differentiation in human cells.
“Transcriptomic analysis revealed that concave niches promoted keratinocyte differentiation, marked by increased type I and II keratin gene expression and downregulation of cell cycle–associated genes.”
Cellsconcave topography compared with a flat matrix3D-bioprinted collagen matricesepidermal stem cell
Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging
bioRxiv (Cold Spring Harbor Laboratory)10 Apr 2026Preprint