GRHL3 expression

Chronological aging is associated with GRHL3 expression in humans.

“Consistently, aged human skin showed reduced KLF4 and GRHL3 and increased SOX9 compared with young skin.”

Humansskin

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

bioRxiv (Cold Spring Harbor Laboratory)·10 Apr 2026Preprint