Sox9 expression

1. High-fat diet decreases Sox9 expression in mice.

   “the HFD reversed the increased expression of progenitor cell markers (Sox9+) and multiple pituitary hormone transcripts seen in the mutant on a control diet.”

   Animalssomatotrope LEPR-null mutants compared with control dietpituitary gland60% high-fat diet16 weeksfemales

   High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes

   Frontiers in endocrinology·16 Jul 2025

More on High-fat diet

1. Chronological aging is associated with Sox9 expression in humans.

   “Consistently, aged human skin showed reduced KLF4 and GRHL3 and increased SOX9 compared with young skin.”

   Humansskin

   Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

   bioRxiv (Cold Spring Harbor Laboratory)·10 Apr 2026Preprint