Cell cycle–associated gene expression

1. Concave niche topography decreases cell cycle–associated gene expression in human cells.

   “Transcriptomic analysis revealed that concave niches promoted keratinocyte differentiation, marked by increased type I and II keratin gene expression and downregulation of cell cycle–associated genes.”

   Cellsconcave topography compared with a flat matrix3D-bioprinted collagen matricesepidermal stem cell

   Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

   bioRxiv (Cold Spring Harbor Laboratory)·10 Apr 2026Preprint

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