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Compressive force

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Deutsche Gesellschaft für Kieferorthopädie and 2 more
  • Cells1

Outcomes

2

Cell migration

upin humans1

1 study

  1. Compressive force increases cell migration in humans.

    “aged fibroblasts can be activated simply through applying compressive force, without the need for exogenous factors, leading to increased migration”

    Reviewin aged fibroblasts

    Identifying regulators of aged fibroblast activation in 3D tissue models

    Scientific reports26 Nov 2025

Osteoclast activation

upin human cells1

1 study

  1. Compressive force increases osteoclast activation in human cells.

    “compressive forces led to increased osteoclast activation.”

    CellsReplicatively senescent cellsperiodontal ligament fibroblast

    GDF15 modulates aging-associated adaptions in the mechanoresponse of periodontal ligament fibroblasts

    Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie15 Jul 2025

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