Commensal bacteria

Intervention

3 papers study it4 findings

Across all fields, 3 papers: none in people yet, 3 in animals

  • 2 independent labs in 2 countries
  • Funders: Japan Agency for Medical Research and Development and others
  • Animals2
  • Model organisms1

Outcomes

4

Reproductive window

upin worms1

1 study
  1. Commensal bacteria increases reproductive window in worms.

    “These effects were accompanied by extending the reproductive window”

    Model organisms

    Natural commensal microbes induce internal hatching in C. elegans

    Microbiology spectrum

Internal hatching

upin worms1

1 study
  1. Commensal bacteria induces internal hatching in worms (28-57% vs <5%).

    “four strains (Ochrobactrum BH3, Lelliottia JUb66, Pantoea BIGb0393, and Enterobacter CEent1) induced high levels of internal hatching (28-57%) in C. elegans during late adulthood”

    Model organisms

    Natural commensal microbes induce internal hatching in C. elegans

    Microbiology spectrum

Senescent microglia

upin mice1

1 study
  1. Commensal bacteria increases senescent microglia in mice.

    “commensal bacteria promote the accumulation of senescent microglia and disease-associated microglia during ageing”

    Animalsduring ageing

    Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

    Communications biology

Cellular senescence

upin mice1

1 study
  1. Commensal bacteria induces cellular senescence in mice.

    “persistent presence of commensal bacteria gradually induces cellular senescence in gut germinal centre B cells”

    Animalspersistent presence of commensal bacteriagut

    Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota

    Nature cell biology

More on Cellular senescence

Funding

1 grant since 2022

National Institute of Diabetes and Digestive and Kidney DiseasesUS$403.8k

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months