Cocoa flavanols

Cocoa flavanols have no effect on ankle-brachial index in humans.

Human trialhypertensive and normotensive participants10.6 to 1,680 mg

Impact of cocoa flavanols on blood pressure and vascular function: an updated systematic review and meta-analysis of randomized controlled trials · The journal of nutrition, health & aging · 1 Sep 2026

Cocoa flavanols decrease pulse wave velocity in humans (MD -0.200 m/s, 95% CI [-0.393, -0.007]).

Human trialhypertensive and normotensive participants10.6 to 1,680 mg

Impact of cocoa flavanols on blood pressure and vascular function: an updated systematic review and meta-analysis of randomized controlled trials · The journal of nutrition, health & aging · 1 Sep 2026

Cocoa flavanols improve flow-mediated dilation in humans (MD 1.314%, 95% CI [1.043, 1.585]).

Human trialhypertensive and normotensive participants10.6 to 1,680 mg

Impact of cocoa flavanols on blood pressure and vascular function: an updated systematic review and meta-analysis of randomized controlled trials · The journal of nutrition, health & aging · 1 Sep 2026

Cocoa flavanols decrease diastolic blood pressure in humans (MD -1.848 mmHg, 95% CI [-2.725, -0.971]).

Human trialhypertensive and normotensive participants10.6 to 1,680 mg

Impact of cocoa flavanols on blood pressure and vascular function: an updated systematic review and meta-analysis of randomized controlled trials · The journal of nutrition, health & aging · 1 Sep 2026

Cocoa flavanols decrease systolic blood pressure in humans (MD -2.734 mmHg, 95% CI [-3.446, -2.023]).

Human trialhypertensive and normotensive participants10.6 to 1,680 mg

Impact of cocoa flavanols on blood pressure and vascular function: an updated systematic review and meta-analysis of randomized controlled trials · The journal of nutrition, health & aging · 1 Sep 2026