Co-culture with normal cells

1. Co-culture with normal cells have no effect on senescent cell elimination in cells.

   “In contrast, p16-induced senescent cells resist elimination under the same co-culture conditions, maintaining high p21 levels.”

   Cellsp16-induced senescent cells

   Elimination of senescent cells by mechanical cell competition

   bioRxiv (Cold Spring Harbor Laboratory)·20 May 2026Preprint

1. Co-culture with normal cells induce mechanical compression of progerin-expressing cells in cells.

   “neighboring normal cells exert persistent mechanical compression on progerin-expressing cells prior to their elimination”

   CellsBefore elimination in co-culture

   Elimination of senescent cells by mechanical cell competition

   bioRxiv (Cold Spring Harbor Laboratory)·20 May 2026Preprint

1. Co-culture with normal cells induce apoptosis in cells.

   “Here we show that progerin-induced senescent cells undergo apoptosis when co-cultured with normal cells.”

   CellsProgerin-induced senescent cells; requires direct cell-cell contact

   Elimination of senescent cells by mechanical cell competition

   bioRxiv (Cold Spring Harbor Laboratory)·20 May 2026Preprint

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