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Circ-osk

Circ-osk has been studied in 1 paper since 2026: none in people yet, 1 in cells; 1 in the past year. No study of it in people or animals has been published yet. The newest story, Oct 23, 2026: “Circular RNA reduced signs of aging in lab-grown stem cells”.

Intervention

1 paper studies it6 findingsUpdated

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Cells1

What did studies of Circ-osk find?

6

Studies of Circ-osk measured 6 outcomes; the most studied are pluripotent conversion (1 study), PI3K–AKT signaling (1) and tri-lineage differentiation capacity (1).

Pluripotent conversion

no changein cells1

1 study

  1. Circ-osk has no effect on pluripotent conversion in cells.

    “we demonstrated that circ-OSK delivery alone is insufficient to transform MSCs into induced pluripotent stem cells (iPSCs).”

    Cellscirc-OSK delivery alonemesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

PI3K–AKT signaling

downin cells1

1 study

  1. Circ-osk inhibits PI3K–AKT signaling in cells.

    “prMSCs restored youthful gene expression and promoted a stress resilient and regenerative transcriptional program via repressing the PI3K-Akt signaling pathway.”

    Cellspartially reprogrammed MSCsmesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

More on PI3K–AKT signaling

Tri-lineage differentiation capacity

upin cells1

1 study

  1. Circ-osk improves tri-lineage differentiation capacity in cells (comparable to early-passage MSCs).

    “restoring proliferative, migratory and tri-lineage differentiation capacities at a level comparable to early-passage MSCs.”

    Cellssenescent late-passage MSCs; compared with early-passage MSCsmesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

DNA damage markers

downin cells1

1 study

  1. Circ-osk decreases DNA damage markers in cells.

    “Circ-OSK-mediated partial reprogramming significantly rejuvenated senescent late-passage MSCs by reducing senescence-associated β-galactosidase activity, DNA damage markers, and inflammatory cytokine secretion”

    Cellssenescent late-passage MSCsmesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

More on DNA damage markers

Inflammatory cytokine secretion

downin cells1

1 study

  1. Circ-osk decreases inflammatory cytokine secretion in cells.

    “Circ-OSK-mediated partial reprogramming significantly rejuvenated senescent late-passage MSCs by reducing senescence-associated β-galactosidase activity, DNA damage markers, and inflammatory cytokine secretion”

    Cellssenescent late-passage MSCsmesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

Senescence-associated beta-galactosidase

downin cells1

1 study

  1. Circ-osk decreases senescence-associated beta-galactosidase in cells.

    “Circ-OSK-mediated partial reprogramming significantly rejuvenated senescent late-passage MSCs by reducing senescence-associated β-galactosidase activity, DNA damage markers, and inflammatory cytokine secretion”

    Cellssenescent late-passage MSCslipid nanoparticle-delivered circular RNAmesenchymal stem cell

    Circular RNA reduced signs of aging in lab-grown stem cells

    Stem cell research & therapy

More on Senescence-associated beta-galactosidase

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months
Stem Cell Research & Therapy

Circular RNA reduced signs of aging in lab-grown stem cells

In an experiment with mesenchymal stem cells, an RNA-based method restored several cell functions without conversion into a more versatile stem cell type.In an experiment with mesenchymal stem cells, an RNA-based method restored several cell functions without conversion into a more versatile stem cell type.

Human cell studyInterventions
Paper

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