Cimicifuga racemosa

1 paper5 findings

Outcomes

Mitochondrial content markers

upin rats1downin rats1

1 study

Cimicifuga racemosa increases mitochondrial content markers in rats.
“decreasing markers associated with mitochondrial content in the soleus while increasing mitochondrial markers in the gastrocnemius.”
Animalshigh-fat diet; non-ovariectomized Wistar ratsextract Ze 450gastrocnemius130 mg/kg/dayfemales
From Myotubes to Skeletal Muscle: Cimicifuga racemosa Extract Ze 450 Preserves Muscle Mass and Affects Skeletal Muscle Energy Metabolism Under Conditions of Metabolic Stress
Cells6 Oct 2026
Cimicifuga racemosa decreases mitochondrial content markers in rats.
“decreasing markers associated with mitochondrial content in the soleus while increasing mitochondrial markers in the gastrocnemius.”
Animalshigh-fat diet; non-ovariectomized Wistar ratsextract Ze 450soleus130 mg/kg/dayfemales
From Myotubes to Skeletal Muscle: Cimicifuga racemosa Extract Ze 450 Preserves Muscle Mass and Affects Skeletal Muscle Energy Metabolism Under Conditions of Metabolic Stress
Cells6 Oct 2026

Muscle mass

no changein rats1

1 study

Cimicifuga racemosa has no effect on muscle mass in rats.
“In vivo, Ze 450 reduced body weight gain and fat accumulation without reducing muscle mass or fiber CSA.”
Animalshigh-fat diet; non-ovariectomized Wistar ratsextract Ze 450skeletal muscle130 mg/kg/dayfemales
From Myotubes to Skeletal Muscle: Cimicifuga racemosa Extract Ze 450 Preserves Muscle Mass and Affects Skeletal Muscle Energy Metabolism Under Conditions of Metabolic Stress
Cells6 Oct 2026

Body-weight gain

downin rats1

1 study

Cimicifuga racemosa decreases body-weight gain in rats.
“In vivo, Ze 450 reduced body weight gain and fat accumulation without reducing muscle mass or fiber CSA.”
Animalshigh-fat diet; non-ovariectomized Wistar ratsextract Ze 450130 mg/kg/dayfemales
From Myotubes to Skeletal Muscle: Cimicifuga racemosa Extract Ze 450 Preserves Muscle Mass and Affects Skeletal Muscle Energy Metabolism Under Conditions of Metabolic Stress
Cells6 Oct 2026

Myotube atrophy

downin mouse cells1

1 study

Cimicifuga racemosa decreases myotube atrophy in mouse cells.
“Ze 450 had limited effects on myotube diameter under basal conditions but significantly attenuated DEX-induced myotube atrophy.”
Cellsdexamethasone-induced atrophyextract Ze 450C2C12 myotube
From Myotubes to Skeletal Muscle: Cimicifuga racemosa Extract Ze 450 Preserves Muscle Mass and Affects Skeletal Muscle Energy Metabolism Under Conditions of Metabolic Stress
Cells6 Oct 2026

1 in 12 months

CellsYesterday

Experiments in ratsMuscle