Chronic intermittent hypoxia

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 3 countries

Funders: Fundação para a Ciência e a Tecnologia and 5 more

Animals1

Outcomes

5

Inflammation

upin humans1no changein rats1

2 studies

Chronic intermittent hypoxia has no effect on inflammation in rats.
“no evidence was found of modifications caused by gestational CIH on markers of hepatic glucose metabolism, inflammation or antioxidant defence”
Animalsgestational exposureliver
Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex
Journal of sleep research14 Nov 2025
Chronic intermittent hypoxia induces inflammation in humans.
“explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation.”
Review
Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved
Biogerontology21 Oct 2025

More on Inflammation

Fractional shortening

downin mice1−16%

1 study

Chronic intermittent hypoxia decreases fractional shortening in mice (-15.8%).
“Compared with CIH alone, EF and FS were reduced by an additional 24.6% and 15.8%, respectively.”
Animalsin Tert-/- mice under CIH vs CIH alone8 weeks
Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability
Aging cell26 Aug 2026

Ejection fraction

downin mice1−25%

1 study

Chronic intermittent hypoxia decreases ejection fraction in mice (-24.6%).
“Compared with CIH alone, EF and FS were reduced by an additional 24.6% and 15.8%, respectively.”
Animalsin Tert-/- mice under CIH vs CIH alone8 weeks
Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability
Aging cell26 Aug 2026

Body weight

no changein rats1

1 study

Chronic intermittent hypoxia has no effect on body weight in rats.
“CIH did not modify body weight, glucose tolerance and insulin sensitivity at 1, 3 and 12 months of age”
Animalsgestational exposurelast 2 weeks of pregnancy
Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex
Journal of sleep research14 Nov 2025

Insulin sensitivity

no changein rats1

1 study

Chronic intermittent hypoxia has no effect on insulin sensitivity in rats.
“CIH did not modify body weight, glucose tolerance and insulin sensitivity at 1, 3 and 12 months of age”
Animalsgestational exposurelast 2 weeks of pregnancy
Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex
Journal of sleep research14 Nov 2025

Latest

1 in 12 months

Journal of Sleep Research14 Nov

Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex

Experiments in ratsHypoxia and HIF signalling

Biogerontology21 Oct

Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved

ReviewMechanisms