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Chaetocin

Intervention

3 papers study it1 more mentions it8 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 2 countries
  • Funders: National Natural Science Foundation of China and 7 more
  • Humans1
  • Animals2

Outcomes

8

P24-expressing CD4+ T cells

upin human cells1

1 study

  1. Chaetocin increases P24-expressing CD4+ T cells in human cells.

    “P24-expressing CD4+T cells increased significantly after chaetocin treatment, indicating HIV latency reversal.”

    Cellsin CD4+ T cells from PLHIVCD4+ T cell

    Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

    Frontiers in agingSep 9, 2025

More on P24-expressing CD4+ T cells

Prelamin A

downin human cells1

1 study

  1. Chaetocin decreases prelamin A in human cells.

    “Treatment with chaetocin increased the global methylation levels and diminished prelamin A accumulation in CD4+ T cells in PLHIV.”

    Cellsin CD4+ T cells from PLHIVCD4+ T cell

    Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

    Frontiers in agingSep 9, 2025

More on Prelamin A

Global DNA methylation

upin human cells1

1 study

  1. Chaetocin increases global DNA methylation in human cells.

    “Treatment with chaetocin increased the global methylation levels and diminished prelamin A accumulation in CD4+ T cells in PLHIV.”

    Cellsin CD4+ T cells from PLHIVCD4+ T cell

    Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

    Frontiers in agingSep 9, 2025

More on Global DNA methylation

Pulmonary hypertension

downin rats1

1 study

  1. Chaetocin decreases pulmonary hypertension in rats.

    “treatment of the specific inhibitor of histone methyltransferase, Chaetocin, effectively attenuates the disease pathogenesis of SuHx-PH in rat.”

    AnimalsSuHx-PH

    The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells

    American journal of physiology. Cell physiologyNov 4, 2024

More on Pulmonary hypertension

MAPK/ERK signaling

upin cells1

1 study

  1. Chaetocin activates MAPK/ERK signaling in cells.

    “prevent this NE budding through sustaining ERK1/2 activation”

    Cells

    Nuclear envelope budding inhibition slows down progerin-induced aging process

    Proceedings of the National Academy of Sciences of the United States of AmericaOct 1, 2024

More on MAPK/ERK signaling

Chromatin loss

downin cells1

1 study

  1. Chaetocin decreases chromatin loss in cells.

    “Chaetocin alleviates NE budding-induced chromatin loss”

    Cells

    Nuclear envelope budding inhibition slows down progerin-induced aging process

    Proceedings of the National Academy of Sciences of the United States of AmericaOct 1, 2024

Progeria

downin mice1

1 study

  1. Chaetocin decreases progeria in mice.

    “ameliorates HGPS defects in cells and mice”

    Animalsin HGPS cells and mice

    Nuclear envelope budding inhibition slows down progerin-induced aging process

    Proceedings of the National Academy of Sciences of the United States of AmericaOct 1, 2024

More on Progeria

Lifespan

upin mice1

1 study

  1. Chaetocin extends lifespan in mice.

    “significantly extends lifespan of HGPS mice”

    Animalsin HGPS mice

    Nuclear envelope budding inhibition slows down progerin-induced aging process

    Proceedings of the National Academy of Sciences of the United States of AmericaOct 1, 2024

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