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CGS-21680

Intervention

1 paper studies it3 findings

PubChemChEBI

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Lisa Dean Moseley Foundation and 3 more
  • Animals1

Outcomes

2

Cellular senescence

downin human cells1downin mice1

1 study

  1. CGS-21680 decreases cellular senescence in mice.

    “A2AR activation reduced nuclear p21 and p16 in obesity-induced OA mice injected with liposomal-CGS21680”

    Animalsin obesity-induced OA miceliposomalcartilage

    Adenosine A2A receptor activation reduces chondrocyte senescence

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

  2. CGS-21680 decreases cellular senescence in human cells.

    “A2AR stimulation of chondrocytes reduced beta-galactosidase staining”

    Cellsliposomalcartilage

    Adenosine A2A receptor activation reduces chondrocyte senescence

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Cellular senescence

AMPK signaling

upin human cells1

1 study

  1. CGS-21680 activates AMPK signaling in human cells.

    “A2AR agonism also increased activity of the chondrocyte Sirt1/AMPK energy-sensing pathway”

    Cellsliposomal

    Adenosine A2A receptor activation reduces chondrocyte senescence

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on AMPK signaling

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