Capsanthin

1. Capsanthin decreases oxidative stress and ROS signalling in mouse cells.

   “leading to reduced oxidative stress (decreased ROS/H2O2, increased MnSOD)”

   Cells

   Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation

   Calcified tissue international·6 Jul 2026

More on Oxidative stress and ROS signalling

1. Capsanthin inhibits NLRP3 inflammasome in mouse cells.

   “suppression of NLRP3 inflammasome activation and pyroptosis, as evidenced by downregulation of NLRP3, caspase-1, IL-1β, and GSDMD.”

   Cells

   Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation

   Calcified tissue international·6 Jul 2026

More on NLRP3 inflammasome

1. Capsanthin inhibits urotensin II signaling pathway in mouse cells.

   “Mechanistically, Cap inhibited the UII/UT axis, leading to reduced oxidative stress (decreased ROS/H2O2, increased MnSOD) and suppression of NLRP3 inflammasome activation and pyroptosis”

   Cells

   Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation

   Calcified tissue international·6 Jul 2026

1. Capsanthin protects against osteoporosis in mice.

   “Cap treatment at 10-20 mg/kg significantly attenuated OVX-induced bone loss, increasing bone mineral density (BMD), improving trabecular microstructure (elevated BV/TV and Tb.Th, reduced Tb.Sp), and enhancing bone strength.”

   Animalsovariectomy-inducedbone10-20 mg/kg12 weeksfemales

   Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation

   Calcified tissue international·6 Jul 2026

More on Osteoporosis