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Caloric restriction serum

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • Funders: National Cancer Institute and 2 more
  • Animals1

Outcomes

1

Oxidative stress and ROS signalling

downin cells1

1 study

  1. Caloric restriction serum decreases oxidative stress and ROS signalling in cells.

    “treatment of CAECs with CR serum attenuated TNFalpha-induced ROS generation”

    Cellsin CAECs treated with TNFalphacoronary arterial endothelial cells

    Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1

    Mechanisms of ageing and development21 Jun 2009

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