Burn injury

6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Institute on Aging and 2 more

Outcomes

Ang4

downin mice1

1 study

Burn injury decreases Ang4 in mice.
“Finally, there was a decrease in the expression of antimicrobial peptide ang4, and not camp in the colons of aged, burn-injured mice.”
Animalsburn injurycolon
Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice
American journal of physiology. Gastrointestinal and liver physiology27 Nov 2025

Associations

SFPI1

upin mice1

1 study

Burn injury is associated with SFPI1 in mice.
“Notably, Ppara and Sfpi1 emerged as potential master regulators of co-expressed genes in burn AT of adult and aged mice, respectively.”
Animalspostburnadipose tissue
Burn Injury Triggers Distinct Transcriptomic Profiles in Adipose Tissue of Adult and Aged Mice
FASEB journal : official publication of the Federation of American Societies for Experimental Biology9 Sep 2025

Burn injury

Outcomes

Associations

Related