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Brain-derived exosomes from aged mice

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

3

TNFRSF25

upin mouse cells1

1 study

  1. Brain-derived exosomes from aged mice increases TNFRSF25 in mouse cells.

    “A-Exo could upregulate the expression of tumor necrosis factor receptor superfamily member 25 (Tnfrsf25) in neurons”

    Cellsin neurons

    Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

    Experimental gerontology16 Oct 2025

More on TNFRSF25

Apoptosis

upin mice1

1 study

  1. Brain-derived exosomes from aged mice induces apoptosis in mice.

    “intranasal A-Exo administration significantly exacerbated spatial memory deficits and hippocampal neuronal apoptosis compared to brain-derived exosomes from young mice (Y-Exo) or controls”

    Animalsin a murine rm-TBI modelhippocampus

    Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

    Experimental gerontology16 Oct 2025

More on Apoptosis

Spatial memory

downin mice1

1 study

  1. Brain-derived exosomes from aged mice impairs spatial memory in mice.

    “intranasal A-Exo administration significantly exacerbated spatial memory deficits and hippocampal neuronal apoptosis compared to brain-derived exosomes from young mice (Y-Exo) or controls”

    Animalsin a murine rm-TBI model

    Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

    Experimental gerontology16 Oct 2025

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