Box a of HMGB1

1. Box a of HMGB1 decreases senescent cells in rats.

   “reduced senescent cells and promoted cell proliferation, as well as accelerated wound confluence, all of which considerably improved wound healing in the group that received Box A treatment.”

   Animalsin burn woundsskin

   HMGB1 release initiates burn wound healing delay via HMGB1-produced DNA gap reduction, promoting DNA damage-hypomethylation-senescence cascade

   Burns : journal of the International Society for Burn Injuries·1 Jun 2026

More on Senescent cells

1. Box a of HMGB1 decreases DNA damage response in rats.

   “a DNA damage marker (γH2A.X) and DNA damage response (DDR) signals (p53, p21, and p16) were all significantly decreased.”

   Animalsin burn woundsskin

   HMGB1 release initiates burn wound healing delay via HMGB1-produced DNA gap reduction, promoting DNA damage-hypomethylation-senescence cascade

   Burns : journal of the International Society for Burn Injuries·1 Jun 2026

More on DNA damage response

1. Box a of HMGB1 increases Alu methylation in rats.

   “Alu methylation levels were significantly increased in the Box A-treated group.”

   Animalsin burn woundsskin

   HMGB1 release initiates burn wound healing delay via HMGB1-produced DNA gap reduction, promoting DNA damage-hypomethylation-senescence cascade

   Burns : journal of the International Society for Burn Injuries·1 Jun 2026

More on Alu methylation