BMP9
4 papers study it4 findings
Across all fields, 4 papers: none in people yet, 2 in animals, 2 in cells
- 2 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 2 more
- Animals2
- Cells2
Outcomes
4SIRT1
downin cells1
1 study
SIRT1
downin cells1
BMP9 decreases SIRT1 in cells.
“We found that SIRT1 expression decreased gradually in a time-dependent manner during BMP9-induced osteogenic differentiation of MSCs.”
Cellsduring BMP9-induced osteogenic differentiationmesenchymal stem cells
Mechanisms of ageing and development
Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
BMP9 inhibits cellular senescence in mouse cells.
“In vitro, Bmp9 treatment inhibits osteoblast senescence through activating Smad1”
Cells
Cell death discovery
Bone biomechanical properties
upin mice1
1 study
Bone biomechanical properties
upin mice1
BMP9 improves bone biomechanical properties in mice.
“BMP9 significantly increases bone mass and improves bone biomechanical properties in aged mice.”
Animals
Cell death discovery
Bone mass
upin mice1
1 study
Bone mass
upin mice1
BMP9 increases bone mass in mice.
“BMP9 significantly increases bone mass and improves bone biomechanical properties in aged mice.”
Animals
Cell death discovery
Funding
1 grant since 2018National Institute on AgingUS$335.6k
Latest
Mechanisms of Ageing and Development
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells
Experiments in cellsInterventions
Cell Death Discovery
BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis
Experiments in miceAge-related bone loss
Osteoarthritis and Cartilage
Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors
Experiments in cellsBones and joints