Biochanin a
- 1 lab in 1 country
- Funders: Innovative Research Group Project of the National Natural Science Foundation of China and 1 more
- Animals1
Outcomes
3Cellular senescence
downin human cells1downin mice1
1 study
Cellular senescence
downin human cells1downin mice1
Biochanin a decreases cellular senescence in human cells.
“BCA treatment effectively attenuated senescence markers and reduced senescence-associated secretory phenotype (SASP) levels in both Ang II-induced HUVECs and naturally aged mice.”
Cellsin Ang II-induced HUVECs and naturally aged mice
Phytomedicine : international journal of phytotherapy and phytopharmacology13 Oct 2025
Biochanin a decreases cellular senescence in mice.
“BCA treatment effectively attenuated senescence markers and reduced senescence-associated secretory phenotype (SASP) levels in both Ang II-induced HUVECs and naturally aged mice.”
Animalsin Ang II-induced HUVECs and naturally aged mice
Phytomedicine : international journal of phytotherapy and phytopharmacology13 Oct 2025
NF-κB signalling
downin human cells1
1 study
NF-κB signalling
downin human cells1
Biochanin a inhibits NF-κB signalling in human cells.
“This inhibition of NFKB1 suppressed NF-κB signaling and the production of SASP factors.”
Cellsvia H3K4me3 suppression at NFKB1 promoter
Phytomedicine : international journal of phytotherapy and phytopharmacology13 Oct 2025
HDAC1
upin human cells1
1 study
HDAC1
upin human cells1
Biochanin a increases HDAC1 in human cells.
“Mechanistically, BCA upregulated HDAC1, which subsequently suppressed the epigenetic aging marker H3K4me3.”
Cellsin HUVECs
Phytomedicine : international journal of phytotherapy and phytopharmacology13 Oct 2025