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Bifidobacterium infantis

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Edward Mallinckrodt, Jr. Foundation and 5 more
  • Model organisms1

Outcomes

2

Oxidative stress protection

downin worms1

1 study

  1. Bifidobacterium infantis protects against oxidative stress protection in worms.

    “Notably, these two strains act through shared (e.g., ATFS-1/ATF5, HSF-1/HFS1, and SKN-1/NRF2) and yet strain-specific pathways (e.g., NHR-49/PPARα for B. infantis) to enhance both lifespan and oxidative stress protection.”

    Model organisms

    Human gut Bifidobacteria strains regulate host longevity via shared and divergent mechanisms in C. elegans

    bioRxiv : the preprint server for biology17 Oct 2025Preprint

Lifespan

upin worms1

1 study

  1. Bifidobacterium infantis extends lifespan in worms.

    “We identified two B. longum and B. infantis strains that most strongly increased lifespan and stress resistance.”

    Model organisms

    Human gut Bifidobacteria strains regulate host longevity via shared and divergent mechanisms in C. elegans

    bioRxiv : the preprint server for biology17 Oct 2025Preprint

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