Beta-sitosterol

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Department of Science and Technology, Ministry of Science and Technology, India and 2 more
5 of 8 findings with company ties

Model organisms2

Outcomes

Lifespan

upin worms2

2 studies

Beta-sitosterol extends lifespan in worms.
“β-sitosterol significantly extended the lifespan of C. elegans”
Model organisms
β-Sitosterol extends lifespan and healthspan in Caenorhabditis elegans via multi-omics analysis of longevity, neuronal, and immune pathways
Biochimica et biophysica acta. General subjects17 Dec 2025
Beta-sitosterol extends lifespan in worms.
“Both BS treatment and ETS-5 knockdown significantly prolonged the lifespan”
Model organisms10 μg/mL
β-sitosterol, an important component in the fruits of Alpinia oxyphylla Miq., prolongs lifespan of Caenorhabditis elegans by suppressing the ferroptosis pathway
Nan fang yi ke da xue xue bao = Journal of Southern Medical University20 Aug 2025

Immune response

upin worms1

1 study

Beta-sitosterol activates immune response in worms.
“β-sitosterol enhanced innate immunity by increasing the expression of antimicrobial peptide genes”
Model organisms
β-Sitosterol extends lifespan and healthspan in Caenorhabditis elegans via multi-omics analysis of longevity, neuronal, and immune pathways
Biochimica et biophysica acta. General subjects17 Dec 2025