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Benzoylbenzoyl-atp

Intervention

1 paper2 findings

PubChem 115205ChEBI 34316

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 4 more
  • Animals1

Outcomes

2

Osteogenic differentiation

upin mouse cells1

1 study

  1. Benzoylbenzoyl-atp increases osteogenic differentiation in mouse cells.

    “Benzoylbenzoyl-ATP enhanced the sensitivity of ERK signaling, thereby enhancing mitochondrial fusion and promoting the osteogenic differentiation of MSCs and bone regeneration.”

    Cellsmesenchymal stem cell

    The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs

    Journal of advanced research13 Jun 2025

Mitochondrial fission and fusion

upin mouse cells1

1 study

  1. Benzoylbenzoyl-atp increases mitochondrial fission and fusion in mouse cells.

    “The activation of P2rx7 in MSCs by Benzoylbenzoyl-ATP enhanced the sensitivity of ERK signaling, thereby enhancing mitochondrial fusion”

    Cellsmesenchymal stem cell

    The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs

    Journal of advanced research13 Jun 2025

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