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Atglistatin

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Austrian Science Fund and 4 more
  • Animals1

Outcomes

3

IL-1β

downin mice1

1 study

  1. Atglistatin decreases IL-1β in mice.

    “atglistatin attenuates HFpEF-associated elevation of inflammatory cytokines, especially IL-1β levels in adipose tissue, more effectively than caloric restriction”

    Animalsobesity-related HFpEFadipose tissue

    Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF

    Cardiovascular diabetology30 Jul 2025

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Diastolic dysfunction

downin mice1

1 study

  1. Atglistatin decreases diastolic dysfunction in mice.

    “leading to superior reduction in adiposity and greater improvement in diastolic dysfunction compared to caloric restriction”

    Animalsobesity-related HFpEF

    Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF

    Cardiovascular diabetology30 Jul 2025

Heart failure with preserved ejection fraction

downin mice1

1 study

  1. Atglistatin decreases heart failure with preserved ejection fraction in mice.

    “pharmacological inhibition of ATGL using atglistatin effectively treats established disease”

    Animalsobesity-related HFpEF

    Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF

    Cardiovascular diabetology30 Jul 2025

More on Heart failure with preserved ejection fraction

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