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Ascorbic acid deficiency

Intervention

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals2

Outcomes

2

PPARG

upin mice1

1 study

  1. Ascorbic acid deficiency increases PPARG in mice.

    “the expression of peroxisome proliferators-activated receptor γ (PPARγ), which is a protein related to lipid metabolism and HSC quiescence, was increased in hypertrophic HSCs by aging and vitamin C (VC) deficiency”

    Animalsin old SMP30-/- miceliver

    Ascorbic acid deficiency accelerates aging of hepatic stellate cells with up-regulation of PPARγ

    Histology and histopathologyFeb 1, 2012

More on PPARG

Lifespan

downin mice1

1 study

  1. Ascorbic acid deficiency shortens lifespan in mice.

    “SMP30 knockout mice were shorter in life span than the wild type when fed autoclaved mouse chow contained approximately 55 mg/kg of vitamin C”

    Reviewin SMP30 knockout mice fed diet with low vitamin Capproximately 55 mg/kg

    Anti-aging research using SMP30/GNL knockout mice

    Yakugaku zasshi : Journal of the Pharmaceutical Society of JapanJan 1, 2010

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