APOE4 genotype
APOE4 genotype has been studied in 4 papers since 2020: 4 observational studies in people; 1 in the past year. The newest paper, Apr 13, 2026: “APOE4 carriers resistant to cognitive decline show unique relationships between cerebrovascular response to exercise and dual-task cognitive-balance performance”.
4 papers study it4 findingsUpdated
See all 4 papers on APOE4 genotype
At a glance
The findings reach people, from one lab or study. 3 independent labs in 1 country.
“We found that ApoE4 carriers had higher hippocampal (d=0.036; p=0.012) and amygdalar (d=0.035; p=0.013) magnetic susceptibility”
None of its findings points the other way.
- 3 independent labs in 1 country
- Funders: National Institute on Aging and others
- Humans4
What did studies of APOE4 genotype find?
3Studies of APOE4 genotype measured 3 outcomes; the most studied are dual-task performance (1 study), brain age (1) and hippocampal magnetic susceptibility (1).
Dual-task performance
no changein humans1
1 study
Dual-task performance
no changein humans1
APOE4 genotype was not clearly linked with dual-task performance in humans.
“No differences in cerebrovascular response or dual-task performance were observed between APOE4 carriers and non-carriers.”
Humansn = 30
Frontiers in neuroscience
Brain age
upin humans1
1 study
Brain age
upin humans1
APOE4 genotype is linked with higher brain age in humans.
“The significant impact of the APOE4 genotype on brain aging and AD risk is also emphasized.”
Humansbrain
Bioengineering (Basel, Switzerland)
Hippocampal magnetic susceptibility
upin humans1
1 study
Hippocampal magnetic susceptibility
upin humans1
APOE4 genotype is linked with higher hippocampal magnetic susceptibility in humans (E3E4+E4E4 carriers versus E3E3) (d=0.036; p=0.012).
“We found that ApoE4 carriers had higher hippocampal (d=0.036; p=0.012) and amygdalar (d=0.035; p=0.013) magnetic susceptibility”
HumansE3E4+E4E4 carriers versus E3E3hippocampus
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
What is APOE4 genotype linked with?
1Studies link APOE4 genotype with 1 measure, most often Alzheimer's disease (1 study).
Alzheimer's disease
upin humans1
1 study
Alzheimer's disease
upin humans1
APOE4 genotype is linked with a higher risk of Alzheimer's disease in humans.
“The significant impact of the APOE4 genotype on brain aging and AD risk is also emphasized.”
Humans
Bioengineering (Basel, Switzerland)