anti-TNFα

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute of Allergy and Infectious Diseases and 1 more

Animals1

Outcomes

Resistance to Streptococcus pneumoniae pulmonary infection

upin mice1

1 study

anti-TNFα increases resistance to Streptococcus pneumoniae pulmonary infection in mice.
“blocking TNFα, one of the SASP factors, altered the senescent-like phenotype and boosted the antibacterial activity of PMNs from aged hosts and increased host resistance”
AnimalsS. pneumoniae pulmonary infectionlung
Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae
Aging cell1 Mar 2026

Latest

1 in 12 months

Aging Cell3 Mar

Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

Experiments in miceSenescence-associated secretory phenotype (SASP)

Paper

anti-TNFα

Outcomes

Latest

Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

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