ANTI-IL11 antibody

1. ANTI-IL11 antibody decreases epigenetic age in mice.

   “Across studies, inhibition of IL11 lowers epigenetic age, reduces telomere attrition, and preserves mitochondrial function.”

   Animals

   Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 9, 2023Preprint

More on Epigenetic age

1. ANTI-IL11 antibody improves physical function in mice.

   “restores muscle function”

   Animalssix months

   Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 9, 2023Preprint

1. ANTI-IL11 antibody decreases frailty in mice.

   “Administration of anti-IL11 therapy to elderly mice for six months reactivates an age-repressed program of white fat beiging, reverses metabolic dysfunction, restores muscle function, and reduces frailty.”

   Animalssix months

   Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 9, 2023Preprint