Anti-dbi antibody
1 paper2 findings
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and others
- Humans1
Outcomes
2Heart failure
downin mice1
1 study
Heart failure
downin mice1
Anti-dbi antibody protects against heart failure in mice.
“antibody-mediated neutralization of DBI/ACBP reduces signs of anthracycline-accelerated cardiac aging including the upregulation of the senescence marker CDKN2A/p16 (cyclin dependent kinase inhibitor 2A) and the functional decline of the heart”
Animalsanthracycline-accelerated cardiac agingheart
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
Autophagy29 Dec 2022
CDKN2A
downin mice1
1 study
CDKN2A
downin mice1
Anti-dbi antibody decreases CDKN2A in mice.
“antibody-mediated neutralization of DBI/ACBP reduces signs of anthracycline-accelerated cardiac aging including the upregulation of the senescence marker CDKN2A/p16”
Animalsanthracycline-accelerated cardiac agingheart
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
Autophagy29 Dec 2022
Latest
Autophagy
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
Cohort study in peopleAutophagy