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Alternative healthy eating INDEX-2010

Alternative healthy eating INDEX-2010 has been studied in 7 papers since 2020: 7 observational studies in people; 3 in the past year. The newest story, Nov 9, 2026: “Eight healthy eating patterns not linked to Parkinson’s risk”.

Intervention

7 papers study it7 findingsUpdated

1 new paper in 30 daysSee all 7 papers on alternative healthy eating INDEX-2010

At a glance

The findings reach people, from one lab or study. 6 independent labs in 3 countries.

“For CLD mortality, significant inverse associations were observed with AHEI-2010 (HR Q4 compared with Q1 = 0.50, 95% CI: 0.27, 0.92, P-trend = 0.02)”
Dietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease MortalityThe Journal of nutrition2026doi:10.1016/j.tjnut.2026.101557

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 6 independent labs in 3 countries
  • Funders: National Institutes of Health and others
  • 2 of 7 findings with company ties
  • Humans7

What did studies of alternative healthy eating INDEX-2010 find?

3

Studies of alternative healthy eating INDEX-2010 measured 3 outcomes: mortality, GrimAge and PhenoAge.

Mortality

downin humans1HR 0.5

1 study

  1. Alternative healthy eating INDEX-2010 is linked with lower mortality in humans (HR 0.50, 95% CI: 0.27, 0.92).

    “For CLD mortality, significant inverse associations were observed with AHEI-2010 (HR Q4 compared with Q1 = 0.50, 95% CI: 0.27, 0.92, P-trend = 0.02)”

    Humans22.1 yfemalesn = 78,345

    Dietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease Mortality

    The Journal of nutrition

GrimAge

downin humans1

1 study

  1. Alternative healthy eating INDEX-2010 is linked with lower GrimAge in humans (per 1-SD increase in diet quality) (β = -0.4 y (95% CI: -0.6 to -0.3 y)).

    “GrimAgeAccel β = -0.4 y (95% CI: -0.6 to -0.3 y)”

    Humansper 1-SD increase in diet qualitywhole bloodfemalesn = 2,694

    Healthy eating patterns and epigenetic measures of biological age

    The American journal of clinical nutrition

More on GrimAge

PhenoAge

downin humans1

1 study

  1. Alternative healthy eating INDEX-2010 is linked with lower PhenoAge in humans (per 1-SD increase in diet quality) (β = -0.5 y (95% CI: -0.8 to -0.2 y)).

    “Of these, the strongest associations were for aHEI-2010 [per 1-SD increase in diet quality, PhenoAgeAccel β = -0.5 y (95% CI: -0.8 to -0.2 y)”

    Humansper 1-SD increase in diet qualitywhole bloodfemalesn = 2,694

    Healthy eating patterns and epigenetic measures of biological age

    The American journal of clinical nutrition

More on PhenoAge

What is alternative healthy eating INDEX-2010 linked with?

4

Studies link alternative healthy eating INDEX-2010 with 4 measures, among them chronic obstructive pulmonary disease, malnutrition and six Minute Walk Test performance.

Chronic obstructive pulmonary disease

downin humans1HR 0.68

1 study

  1. Alternative healthy eating INDEX-2010 is associated with chronic obstructive pulmonary disease in humans (Individuals with type 2 diabetes) (HR 0.68 (95% CI 0.52–0.88), 90th versus 10th percentile).

    “the healthy low-carbohydrate diet (HLCD), alternative healthy eating index-2010 (AHEI), and the reversed energy-adjusted dietary inflammatory index (rEDII) tended to show more pronounced inverse associations with COPD.”

    HumansIndividuals with type 2 diabetes90th versus 10th percentile of dietary pattern scoresMedian follow-up of 10.3 yearsn = 7,542

    Dietary Patterns, Metabolomic Profiling, and Risk of Chronic Obstructive Pulmonary Disease in Individuals with Type 2 Diabetes

    Nutrition research (New York, N.Y.)

More on Chronic obstructive pulmonary disease

Malnutrition

downin humans1OR 0.65

1 study

  1. Alternative healthy eating INDEX-2010 is linked with a lower risk of malnutrition in humans (pooled OR 0.65 (95% CI 0.49-0.86)).

    “Higher adherence to the AHEI-2010 also showed an inverse association with malnutrition (pooled odds ratio for quartile 4 vs. 1: 0.65 (0.49-0.86); p-trend 0.006).”

    Humans

    Association between diet quality and malnutrition: pooled results from two population-based studies in older adults

    BMC geriatrics

More on Malnutrition

Six Minute Walk Test performance

upin humans1

1 study

  1. Alternative healthy eating INDEX-2010 is associated with six Minute Walk Test performance in humans.

    “Adjusting for total calories, AHEI-2010 total score was associated with superior performance on the six-minute walk test.”

    Humansadjusted for total calories only; association attenuated with further adjustment for age, gender, BMI, waist circumference, self-reported pain and physical activityn = 413

    Association of diet quality and physical function among overweight and obese primarily African American older adults with lower extremity osteoarthritis

    Nutrition and healthy aging

Healthy aging

upin humans1OR 1.39

1 study

  1. Alternative healthy eating INDEX-2010 is associated with healthy aging in humans (highest vs lowest quartile of midlife diet score) (OR 1.39 (95% CI 1.23-1.57)).

    “1.39 (1.23-1.57) for AHEI-2010”

    Humanshighest vs lowest quartile of midlife diet scoren = 14,159

    Association Between Dietary Patterns in Midlife and Healthy Ageing in Chinese Adults: The Singapore Chinese Health Study

    Journal of the American Medical Directors Association

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 03 papers in 12 months
Movement Disorders

Eight healthy eating patterns not linked to Parkinson’s risk

Two US cohorts of 70,973 women and 45,820 men followed for up to 32 years showed no association across eight healthy dietary patterns.Two US cohorts of 70,973 women and 45,820 men followed for up to 32 years showed no association across eight healthy dietary patterns.

Cohort studyParkinson's disease
Paper

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