Healthful plant-based diet index

5 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: National Natural Science Foundation of China

Humans5

Outcomes

Mortality

downin humans1HR 0.72

1 study

Healthful plant-based diet index decreases mortality in humans (HR = 0.72, 95%CI: 0.55-0.95).
“Among 3,397 breast cancer patients, the highest HPDI tertile showed 28% lower mortality (HR = 0.72, 95%CI: 0.55-0.95) vs. lowest”
Humansvs. lowest tertile in breast cancer patientsn = 3,397
Plant-based dietary patterns, micronutrient status and breast cancer outcomes: a joint analysis of UK Biobank and Chinese longitudinal healthy longevity survey
Frontiers in nutrition26 Jan 2026

Associations

Breast cancer

downin humans1HR 0.89

1 study

Healthful plant-based diet index lowers the risk of breast cancer in humans (HR = 0.89, 95%CI: 0.82-0.98).
“the highest HPDI tertile was associated with 11% lower breast cancer risk (HR = 0.89, 95%CI: 0.82-0.98) vs. lowest tertile”
Humansvs. lowest tertilen = 67,045
Plant-based dietary patterns, micronutrient status and breast cancer outcomes: a joint analysis of UK Biobank and Chinese longitudinal healthy longevity survey
Frontiers in nutrition26 Jan 2026