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α-ketoglutarate dehydrogenase inhibitors

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

Outcomes

1

Effector T cell activity

upin mice1

1 study

  1. α-ketoglutarate dehydrogenase inhibitors improve effector T cell activity in mice.

    “Notably, pharmacologic inhibition of α-ketoglutarate dehydrogenase reversed this effect, restoring effector T cell activity.”

    Animalssuccinate-associated immunosuppression in epithelial ovarian cancerovarian tumor microenvironment

    Aging-Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

    bioRxiv : the preprint server for biology11 Aug 2025Preprint

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