Allyl isothiocyanate

1. Allyl isothiocyanate has no effect on basal antimicrobial peptide expression in flies.

   “AITC did not affect the flies' feed intake or basal AMP expression under non-infected conditions.”

   Model organismsnon-infected flies0.25 mM

   Impact of allyl-isothiocyanate and high sucrose diet on antimicrobial peptide expression and survival in Drosophila melanogaster

   Frontiers in immunology·10 Apr 2026

More on Basal antimicrobial peptide expression

1. Allyl isothiocyanate increases mortality in flies.

   “with AITC frequently exacerbating mortality rather than improving outcomes.”

   Model organismshigh-sucrose diet and oral infection; pathogen-specific effects0.25 mMsex-specific effectss

   Impact of allyl-isothiocyanate and high sucrose diet on antimicrobial peptide expression and survival in Drosophila melanogaster

   Frontiers in immunology·10 Apr 2026

1. Allyl isothiocyanate has no effect on lifespan in flies.

   “HSD significantly shortened the lifespan in both sexes, and AITC supplementation was not able to rescue this effect.”

   Model organismshigh-sucrose diet0.25 mM

   Impact of allyl-isothiocyanate and high sucrose diet on antimicrobial peptide expression and survival in Drosophila melanogaster

   Frontiers in immunology·10 Apr 2026

1. Allyl isothiocyanate decreases cardiac fibrosis in mice (P < 0.01).

   “Histological analyses revealed decreased cardiac fibrosis and collagen I/III deposition in AITC-treated mice (all P < 0.01).”

   Animalsmyocardium15 mg of AITC per kilogram of food6 months

   Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice

   GeroScience·12 Mar 2025

1. Allyl isothiocyanate increases heart rate variability in mice (P < 0.01).

   “AITC treatment significantly increased heart rate variability (P < 0.01)”

   Animalsheart15 mg of AITC per kilogram of food6 months

   Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice

   GeroScience·12 Mar 2025

1. Allyl isothiocyanate improves diastolic function in mice (P < 0.01).

   “AITC treatment significantly improved diastolic function by normalizing the E/A ratio (P < 0.01)”

   Animalsheart15 mg of AITC per kilogram of food6 months

   Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice

   GeroScience·12 Mar 2025