Alagebrium

Alagebrium has no effect on cognitive function in mice.

“There was no effect of ALT-711 on cerebral artery endothelial function, cognitive function, or collagen crosslinking.”

Animalsoral gavage1 mg/kg/day4 months

Age-related arterial stiffness and cerebrovascular dysfunction in mice correlate with cognitive impairment but are not reduced with long-term ALT-711 treatment

Physiological reports·1 Jun 2026

Alagebrium has no effect on arterial stiffness in mice.

“Treatment with ALT-711 did not significantly reduce stiffness in large arteries or cerebral arteries.”

Animalsoral gavage1 mg/kg/day4 months

Age-related arterial stiffness and cerebrovascular dysfunction in mice correlate with cognitive impairment but are not reduced with long-term ALT-711 treatment

Physiological reports·1 Jun 2026