Adenine base editor

Intervention1 paper3 findings

Animals1

Outcomes

3

Bone structural and physical parameters

upin mice1Very low certainty

1 study

Adenine base editor improves bone structural and physical parameters in mice.
Animalsin HGPS transgenic micebone
In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson-Gilford Progeria Syndrome · Aging cell · 1 Sep 2026

Extracellular matrix remodelling

upin mouse cells1Very low certainty

1 study

Adenine base editor improves extracellular matrix remodelling in mouse cells.
Cellsprogeroid osteoblasts in vitro
In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson-Gilford Progeria Syndrome · Aging cell · 1 Sep 2026

Extracellular matrix remodelling →

Progerin

downin mouse cells1Very low certainty

1 study

Adenine base editor decreases progerin in mouse cells.
Cellsin double-copy transgenic osteoblast cultures
In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson-Gilford Progeria Syndrome · Aging cell · 1 Sep 2026

Latest

1

Aging CellAnimals3 Sep

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

Bones and joints