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Acipimox

Intervention

3 papers3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funder: Japan Society for the Promotion of Science
  • Animals2

Outcomes

3

Mortality

downin mice1

1 study

  1. Acipimox decreases mortality in mice.

    “These alterations in fat regulation were inhibited by the lipolysis inhibitor, acipimox, a treatment associated with reduced mortality.”

    Animalsin NPY-/- mice during CRmales

    Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction

    Aging cell19 Jan 2017

Autophagy

upin rats1

1 study

  1. Acipimox increases autophagy in rats.

    “autophagic proteolysis decreased in mature and older AL rats; EOD and FWA fully counteracted these changes”

    Animalsonce-weekly fasting with acipimox (FWA)liver50 mg/kg b.w.males

    Anti-aging effects of anti-lipolytic drugs

    Experimental gerontology1 Jul 2004

More on Autophagy

Insulin

downin rats1

1 study

  1. Acipimox decreases insulin in rats.

    “Treatment with ACIPIMOX transiently decreased plasma free fatty acids, glucose and insulin and increased valine plasma levels”

    Animalson the day of fasting once a weekgastric tubeplasma50 mg/kg b.w.males

    Anti-aging effects of anti-lipolytic drugs

    Experimental gerontology1 Jul 2004

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