Acetylcysteine + vitamin D

1. Acetylcysteine + vitamin D decreases CDKN2A in humans.

   “co-administration of NAC with 1000 IU of Vit-D significantly downregulated p16 transcripts in PBMCs compared to Vit-D 1000 IU alone.”

   Human trialvitamin D deficiencyPBMCs1000 IU Vit-D plus 600 mg of NAC daily vs 1000 IU Vit-D daily8 weeks

   Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial

   Frontiers in immunology·12 May 2025

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