ADT1 inhibitor + acetyl-coa + alpha-ketoglutarate

1 paper1 finding

1 lab in 1 country

Funders: Guangdong Provincial Pearl River Talents Program and 2 more

Animals1

Outcomes

1

Cellular senescence

downin human cells1

1 study

ADT1 inhibitor + acetyl-coa + alpha-ketoglutarate decreases cellular senescence in human cells.
“Thus, combination therapy with an ADT1 inhibitor, supplemented with acetyl-CoA and α-KG, corrected hEV-induced metabolic reprogramming and cellular fate changes, restoring impaired chondrogenesis and aging in OA CSPCs and OA models.”
Cellsin OA CSPCs and OA models
Hybrid extracellular vesicles drive irreversible mitochondria damage and TCA metabolite deficiency-related chondrocyte senescence
Innovation (Cambridge (Mass.))5 Jan 2026

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