AAV9-GFAP-CDKN2A
1 paper3 findings
- 1 lab in 1 country
- Animals1
Outcomes
3Brain mass
no changein mice1
1 study
Brain mass
no changein mice1
AAV9-GFAP-CDKN2A has no effect on brain mass in mice.
“At tissue collection, we did not observe significant effects of Cdkn2a over‐expression on brain mass”
Animalsastrocytic over-expression in PS19 and NonTg miceanterior cortex and hippocampus4 months
Increased Cdkn2a , a regulator of cellular senescence, in the PS19 mouse model of tauopathy
AAIC 2025 abstract25 Dec 2025
Learning and memory
no changein mice1
1 study
Learning and memory
no changein mice1
AAV9-GFAP-CDKN2A has no effect on learning and memory in mice.
“Finally, we did not observe significant effects of Cdkn2a over‐expression on hippocampal dependent learning and memory as measured by the radial arm water maze.”
Animalsastrocytic over-expression in PS19 and NonTg miceanterior cortex and hippocampus4 months
Increased Cdkn2a , a regulator of cellular senescence, in the PS19 mouse model of tauopathy
AAIC 2025 abstract25 Dec 2025
Pre-pulse inhibition of acoustic startle response
upin mice1
1 study
Pre-pulse inhibition of acoustic startle response
upin mice1
AAV9-GFAP-CDKN2A improves pre-pulse inhibition of acoustic startle response in mice.
“Surprisingly, we did observe a significant improvement in pre‐pulse inhibition of the acoustic startle response in PS19 mice over‐expressing Cdkn2a in astrocytes.”
Animalsastrocytic over-expression in PS19 miceanterior cortex and hippocampus4 months
Increased Cdkn2a , a regulator of cellular senescence, in the PS19 mouse model of tauopathy
AAIC 2025 abstract25 Dec 2025